{"title":"C-reactive protein and atrial fibrillation. Is inflammation a consequence or a cause of atrial fibrillation?","authors":"Naoyuki Sata, Naokazu Hamada, Takashi Horinouchi, Shigeru Amitani, Takuya Yamashita, Yukinori Moriyama, Kenkichi Miyahara","doi":"10.1536/jhj.45.441","DOIUrl":null,"url":null,"abstract":"<p><p>To clarify whether inflammation is a cause or consequence of atrial fibrillation (AF), we measured high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) before and after pharmacological cardioversion in 15 patients with paroxysmal AF. Levels of hs-CRP, IL-6, and TNF-alpha after cardioversion were significantly higher than those in controls (P < 0.05). Furthermore, the levels of these indices did not differ significantly even at 24 hours and 2 weeks after cardioversion. These results suggest that inflammation is a causative agent of paroxymal AF.</p>","PeriodicalId":14717,"journal":{"name":"Japanese heart journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2004-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1536/jhj.45.441","citationCount":"168","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese heart journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1536/jhj.45.441","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 168
Abstract
To clarify whether inflammation is a cause or consequence of atrial fibrillation (AF), we measured high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) before and after pharmacological cardioversion in 15 patients with paroxysmal AF. Levels of hs-CRP, IL-6, and TNF-alpha after cardioversion were significantly higher than those in controls (P < 0.05). Furthermore, the levels of these indices did not differ significantly even at 24 hours and 2 weeks after cardioversion. These results suggest that inflammation is a causative agent of paroxymal AF.
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