A novel promoter polymorphism (-71C>T) in KRTHB6 gene in Indian population

Abstract

We have screened the basal promoter region, of KRTHB6 gene involving CAAT and TATA boxes in randomly selected 125 individuals of Indian origin by PCR-SSCP and DNA sequencing. We observed a novel promoter polymorphism (-71C>T) which could be differentiated by using LweI restriction enzyme. The frequency of –71 C allele, allele A (Accession no AY203963), was observed to be higher ( 0.712) in comparison to –71 T allele, allele B (0.288) (Accession no. AY037552).