Intranuclear filamentous inclusion in human oedematous cerebellar Golgi cells.

Abstract

The presence of intranuclear filamentous inclusions in cerebellar Golgi cells is reported in three patients with cerebellar tumours. Samples of cerebellar cortex were processed for conventional transmission electron microscopy. Cerebellar biopsies were performed according to the basic principles of Helsinki declaration. Intranuclear inclusions observed in oedematous Golgi cells, appeared as straight rodlets up to 3 microm in length and up to 0.4 microm in width, characterized by a periodic or crystalloid structure formed by dense bands, 9.2 nm thick separated by clear spaces, 5.4 nm in width. These structures are considered abnormal protein aggregates apparently induced by excitotoxicity, oxidative stress and impaired energy metabolism.