A simple, safe, and efficient way to treat severe fluoride poisoning--oral calcium or magnesium.

Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01 DOI:10.1081/clt-120028742

Wei-Fong Kao, Jou-Fang Deng, Shu-Chiung Chiang, Kennon Heard, David H T Yen, Mei-Chun Lu, Benjamin Ing-Tiau Kuo, Chien-Chun Kuo, Tsung-Yun Liu, Chen-Hsen Lee

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引用次数: 13

Abstract

Purpose: To examine the efficacy and safety of administration of calcium and magnesium orally and intraperitoneally to treat severe sodium fluoride intoxication.

Materials and methods: Mice were initially gavaged a lethal dose of sodium fluoride (NaF) or water. Then, mice were treated with water or varying concentrations of calcium chloride (CaCl2) or magnesium sulfate (MgSO4) via intraperitoneal (IP) route or via oral route. Mice were monitored for 24 h, and the time of death was recorded.

Results: IP injections of large amounts of CaCl2 or MgSO4 were dangerous. All mice gavaged with water and then treated with oral CaCl2 or MgSO4 survived and displayed normal activity during the experiment. The survival rate of mice gavaged with a lethal dose of NaF and then treated with a high dose of oral CaCl2 or MgSO4 was significantly higher than those of using low dose.

Conclusion: Oral administration of a high dose of CaCl2 or MgSO4 is a simple, safe, and effective adjunctive method for treating severe oral fluoride poisoning.

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一种简单、安全、有效的治疗严重氟化物中毒的方法——口服钙或镁。

目的:探讨口服和腹腔注射钙镁治疗重度氟化钠中毒的疗效和安全性。材料和方法:小鼠先灌胃致死剂量的氟化钠(NaF)或水。然后，通过腹腔或口服给药，分别给予水或不同浓度的氯化钙(CaCl2)或硫酸镁(MgSO4)。小鼠监测24 h，记录死亡时间。结果:IP注射大量CaCl2或MgSO4是危险的。所有小鼠均经水灌胃后口服CaCl2或MgSO4，实验期间均存活并表现出正常的活动。致死剂量NaF灌胃后，大剂量口服CaCl2或MgSO4处理小鼠的存活率显著高于小剂量小鼠。结论:口服大剂量氯化钙或硫酸镁是治疗重度口服氟化物中毒的一种简单、安全、有效的辅助方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of toxicology. Clinical toxicology

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