C-cells in colloid goiter.

Revista do Hospital das Clinicas Pub Date : 2003-11-01 Epub Date: 2004-01-28 DOI:10.1590/s0041-87812003000600004

Marcus A Lima, Fabiana S Tiveron, Vitorino M Santos, Lilian M B Lima, Gilberto P Silva, Maria F Borges

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引用次数: 3

Abstract

Purpose: The aim of this investigation was to quantitatively evaluate C-cells in colloid goiters, analyzing 36 thyroids that were obtained through thyroidectomy from 24 patients with goiter and 12 normal glands from adult patients without thyroid disease, which were used as the control group.

Material and methods: On average, 6 different thyroid areas were sampled and labeled by immunohistochemistry with a monoclonal anticalcitonin antibody, utilizing the avidin-biotin-peroxidase complex. C-cells were counted in fields measuring 1 square centimeter, and the mean number of cells per field was then calculated. Data were statistically analyzed using the Mann-Whitney test.

Results: In the colloid goiter group, the number of C-cells ranged from 0 to 23 per field, while in normal controls they ranged from 20 to 148 per field.

Conclusions: These results demonstrate a significant decrease of C-cell number in the colloid goiter group compared with control group, indicating that the hyperplastic process is restricted to follicular cells, to the detriment of C-cells, which probably cease to receive trophic stimuli.

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胶体甲状腺肿中的c细胞。

目的:本研究的目的是定量评价胶体性甲状腺肿中的c细胞，分析24例甲状腺肿患者甲状腺切除术获得的36个甲状腺和未患甲状腺疾病的成年患者的12个正常腺体作为对照组。材料和方法:平均选取6个不同的甲状腺区域，利用亲和素-生物素-过氧化物酶复合物，用单克隆抗降钙素抗体进行免疫组织化学标记。在1平方厘米的视野中计数c细胞，然后计算每个视野的平均细胞数。数据采用Mann-Whitney检验进行统计学分析。结果:胶体甲状腺肿组c细胞数量为0 ~ 23个/野，正常对照组为20 ~ 148个/野。结论:这些结果表明，与对照组相比，胶体甲状腺肿组c细胞数量明显减少，表明增生过程仅限于滤泡细胞，损害了c细胞，其可能停止接受营养刺激。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista do Hospital das Clinicas

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