Left ventricular remodeling: pathophysiology and treatment.

Heart failure monitor Pub Date : 2003-01-01
Norman Sharpe
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引用次数: 0

Abstract

Left ventricular (LV) remodeling, which can result from myocardial damage or ventricular pressure or volume overload, has genomic, cellular, and interstitial components with associated changes in ventricular size, shape, wall thickness, and function. It is a process that is detectable and measurable clinically, generally progressive, and associated with adverse outcomes. However, it is amenable to intervention, prevention, or reversal. Following myocardial infarction (MI), LV remodeling is particularly likely in patients with transmural or anterior infarction and in those with failed reperfusion or LV failure. Infarct artery patency and neurohormonal blockade are key management considerations for prevention or reversal of LV remodeling. Combination treatment with angiotensin-converting enzyme inhibition and beta-blockade is of proven benefit following MI, improving LV remodeling and long-term outcomes.

左心室重构:病理生理及治疗。
左心室(LV)重构可由心肌损伤、心室压力或容量过载引起,具有基因组、细胞和间质成分,并与心室大小、形状、壁厚和功能的变化相关。这是一个可在临床上检测和测量的过程,通常是进行性的,并与不良后果相关。然而,它是可以干预、预防或逆转的。心肌梗死(MI)后,左室重构特别可能发生在经壁或前壁梗死患者以及再灌注失败或左室衰竭患者中。梗死动脉通畅和神经激素阻断是预防或逆转左室重构的关键管理考虑因素。血管紧张素转换酶抑制和β -阻断联合治疗在心肌梗死后被证明是有益的,可以改善左室重塑和长期预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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