Calcium concentration at rat females with osteoporosis after applying calcium fumarate.

Abstract

The dynamics of total calcium concentration in blood of rat females with osteoporosis caused experimentally after applying it in the form of fumarate was determined. The fumarate was applied in just one dose by the means of stomach tube at the dose of teoporoz_ 4.28 mg of calcium/100 g of body mass. The total calcium concentration in blood was determined: 0; 1; 2; 3; 5 i 7 h after application. It was observed that one hour after application calcium concentration in control group increased by 19.3%, and in the group of animals after ovariectomy it decreased by 6.7% (P < 0.001). After 2 h calcium concentration in both groups returned to its initial state, and after 3 hours three next decrease in relation to initial time by 10% occurred in the control group and by 4% in the group after ovariectomy. Between 4 h and 7 h after administration calcium concentration in both groups of animals was even and it was maintaining at the constant level in the range 2.248-2.172 mM/l.