Norepinephrine-induced delayed cardioprotection against stunning is at the expense of a higher postischemic arrhythmia rate

Cardiovascular surgery (London, England) Pub Date : 2003-12-01 DOI:10.1016/S0967-2109(03)00115-7

Ralph Marktanner , Peter Nacke , Peter Feindt , Thomas Hohlfeld , Emmeran Gams

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Abstract

Objective: α₁-adrenoceptor activation confers myocardial protection from ischemic injury. We tested whether norepinephrine mediates delayed cardioprotection against stunning and whether this alters postischemic arrhythmias.

Methods: New Zealand White rabbits were assigned to three groups: Control-group (n=7): no drugs. Norepinephrine-group (n=7): 75 μg norepinephrine/kg bodyweight (bw). Norepinephrine/prazosin-group (n=7):75 μg norepinephrine and 15 μg prazosin/kg bw. After 24 h, hearts were excised, perfused with buffer and subjected to 20 min of ischemia followed by 120 min of reperfusion.

Results: (a) Developed pressures (dP) (P_syst−P_diast) at the end of reperfusion: C: 51.2±5.0%, NE: 71.7±5.1% (p<0.05 vs. C), NEP: 50.7±5.0%. (b) Ventricular extra beats (vebs) were detected throughout the experiments. C: 0.41±0.15 vebs/min, NE: 1.06±0.18 vebs/min (p<0.05 vs. C), NEP: 1.17±0.3 vebs/min.

Conclusion: Norepinephrine confers delayed preconditioning against myocardial stunning via an α₁-adrenoceptor mediated pathway. Norepinephrine-mediated preconditioning involves a beneficial effect towards stunning, but at the expense of a higher rate of postischemic ventricular arrhythmia.

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去甲肾上腺素诱导的迟发性心脏保护，是以较高的缺血性心律失常率为代价的

目的:α1-肾上腺素能受体激活对心肌缺血损伤具有保护作用。我们测试了去甲肾上腺素是否介导延迟的心脏保护以防止休克，以及这是否会改变缺血性心律失常。方法:将新西兰大白兔分为3组:对照组(n=7):不给药。去甲肾上腺素组(n=7):去甲肾上腺素75 μg /kg体重。去甲肾上腺素/普拉唑辛组(n=7):去甲肾上腺素75 μg /kg bw，普拉唑辛15 μg /kg bw。24 h后，切除心脏，灌注缓冲液，缺血20 min，再灌注120 min。结果:(a)再灌注结束时发育压力(dP) (Psyst−Pdiast): C: 51.2±5.0%，NE: 71.7±5.1% (p<0.05 vs. C)， NEP: 50.7±5.0%。(b)在整个实验过程中检测到心室外搏(vebs)。C: 0.41±0.15 vebs/min, NE: 1.06±0.18 vebs/min (p < 0.05)， NEP: 1.17±0.3 vebs/min。结论:去甲肾上腺素通过α - 1肾上腺素受体介导的途径对心肌休克的延迟预适应起作用。去甲肾上腺素介导的预处理对眩晕有有益作用，但代价是缺血性室性心律失常的发生率较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cardiovascular surgery (London, England)

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