The effect of the chemical composition of albumin-containing microcapsules upon their properties.

Abstract

The effect of the composition of the coating (gelatine, sodium alginate, acetic acid) covering the biodegradable microcapsules upon their efficiency as well as upon albumin incorporation percentage value, were determined by the method of the 3 x 3 Latin squares. Selected physical and chemical properties of the microcapsules as well as the rate of albumin release from the microcapsules were investigated. Microcapsules suitable for parenteral administration were prepared using the method of a complex coacervation with the model substance: human albumin. None of the selected components of the coating was found to have any significant effect upon the efficiency of the microcapsules. However, it was established that the albumin incorporation effect was significantly influenced by gelatine concentration in the composition of the component. Based on the attained results, the composition of the biodegradable capsules was determined: 5% gelatine; 3% sodium alginate; and 25% acetic acid. Using the gelatin-sodium alginate system, microcapsules containing albumin with a prolonged release time, suitable for parenteral administration, were obtained.