The effect of systemic administration of haematin on the tryptophan pyrrolase activity of rat liver

Abstract

The saturation with cofactor of the tryptophan pyrrolase of rat liver was markedly increased by intravenous administration of solutions of haematin. Complete saturation followed the administration of 0.5–1 μmole haematin per 100 g body weight or larger amounts. No significant increase in tryptophan pyrrolase activity accompanied or followed this apparent saturation of the enzyme with cofactor in vivo.