Separation of normal human transferrin into two fractions

Abstract

Ethanol-fractionated human transferrin (transferrin CC) separates into two fractions when subjected to chromatography on anion-exchange cellulose (CM-cellulose). The two fractions show similarities in their immunological, biological and physical properties. Some differences in their carbohydrate composition are demonstrated.

The same separation pattern of transferrin is found if whole serum from individual donors is subjected to the same chromatographic procedure.