{"title":"Metabolism in vivo of [7α-3H]pregnenolone by the dog ovary","authors":"Jose Depaoli , Kristen B. Eik-Nes","doi":"10.1016/0006-3002(63)90907-7","DOIUrl":null,"url":null,"abstract":"<div><p>In order to determine if the ovarian metabolism of pregnenolone differed between estrus and pregnancy, [7α-<sup>3</sup>H]pregnenolone was infused by the ovarian artery in anesthetized dogs and steroids containing tritium isolated in ovarian vein blood. </p><ul><li><span>1.</span><span><p>1. Within 5 min the canine ovary metabolized pregnenolone to 17α-hydroxy-pregnenolone, progesterone, 17α-hydroxyprogesterone, dehydroepiandrosterone, androsterone, testosterone and probably estradiol.</p></span></li><li><span>2.</span><span><p>2. Induction of mating in the female dog by treatment with human chorionic gonadotropin was associated with a high capacity of the ovary to convert pregnenolone to testosterone and androstenedione.</p></span></li><li><span>3.</span><span><p>3. Dogs in the early part of pregnancy metabolized a considerable amount of the infused pregnenolone to progesterone.</p></span></li></ul></div>","PeriodicalId":94301,"journal":{"name":"Biochimica et biophysica acta","volume":"78 3","pages":"Pages 457-465"},"PeriodicalIF":0.0000,"publicationDate":"1963-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0006-3002(63)90907-7","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et biophysica acta","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0006300263909077","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
In order to determine if the ovarian metabolism of pregnenolone differed between estrus and pregnancy, [7α-3H]pregnenolone was infused by the ovarian artery in anesthetized dogs and steroids containing tritium isolated in ovarian vein blood.
1.
1. Within 5 min the canine ovary metabolized pregnenolone to 17α-hydroxy-pregnenolone, progesterone, 17α-hydroxyprogesterone, dehydroepiandrosterone, androsterone, testosterone and probably estradiol.
2.
2. Induction of mating in the female dog by treatment with human chorionic gonadotropin was associated with a high capacity of the ovary to convert pregnenolone to testosterone and androstenedione.
3.
3. Dogs in the early part of pregnancy metabolized a considerable amount of the infused pregnenolone to progesterone.
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