Preparation of Tritium-Labeled Halothane (2-Bromo-2-chloro-1,1,1-trifluoroethane)*

Abstract

Halothane was labeled with tritium (Wilzbach method) by exposure to 2.3 curies of tritium gas for fourteen days. The one hydrogen of the molecule was labeled and on purification gave a final specific activity of 2.9 mc. per Gm. In the preparation a considerable amount of ‘loose’ tritium and highly active impurities were separated and the purity of the final product following gas chromatographic purification was better than 99.95 per cent.