Evaluation of nucleotide derivatives and sugar nucleotide analogs as inhibitors of glycosyltransferases.

K Osumi, N Kawauchi, A H Lu, O Hindsgaul, M M Palcic
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Abstract

The inhibition of glycosyltransferases was studied using uridine monophosphate derivatives and uridine diphosphate sugar analogs. Modification in the nucleoside portion caused selective inhibition of glycosyltransferases.

核苷酸衍生物和糖核苷酸类似物作为糖基转移酶抑制剂的评价。
研究了单磷酸尿苷衍生物和二磷酸尿苷糖类似物对糖基转移酶的抑制作用。核苷部分的修饰引起糖基转移酶的选择性抑制。
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