Introduction of a benzoyl group onto 6-chloropurine riboside in aqueous solution and its application to the synthesis of nucleoside derivatives.

T Maruyama, S Kozai, S Takamatsu, K Izawa
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Abstract

A benzoyl group was introduced onto the 3'-hydroxyl group of 6-chloropurine riboside by treatment with benzoic anhydride in the presence of a base in aqueous solution. The product (3b) was converted to 9-(2,3-Di-deoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine (1, FddA) in 6 steps, including radical deoxygenation.

6-氯嘌呤核苷水溶液中苯甲酰基团的引入及其在核苷衍生物合成中的应用。
用苯甲酸酐处理6-氯嘌呤核苷,在水溶液中有碱存在的情况下,在6-氯嘌呤核苷的3′-羟基上引入了一个苯甲酰基团。产物(3b)经过6步转化为9-(2,3-二脱氧-2-氟- β -d -三戊呋喃基)腺嘌呤(1,fda),包括自由基脱氧。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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