An efficient synthesis of nucleotides via the phosphoramidite method using a triflic acid salt of an imidazole-related compound as a promoter.

A Sakakura, M Kataoka, R Kawai, Y Hayakawa
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引用次数: 1

Abstract

N-Phenylimidazolium triflate and N-methylbenzimidazolium triflate, new imidazole-related compound/triflic acid-complex type of promoters in the phosphoramidite method, has been developed. These reagents are, particularly, useful for internucleotide-bond formation with lowly reactive reactants and have allowed an efficient, high-yield synthesis of oligodeoxyribonucleotides both in a solution phase and on a solid supports.

利用咪唑相关化合物的三羧酸盐作为启动子,通过磷酰胺法有效地合成核苷酸。
研究了咪唑相关化合物/三氟酸配合型促进剂n -苯基咪唑三氟酸和n -甲基咪唑三氟酸。这些试剂特别适用于与低反应性反应物形成核苷酸间键,并且可以在溶液和固体载体上高效、高产地合成寡脱氧核糖核苷酸。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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