Design and synthesis of curcumin-bioconjugates to improve systemic delivery.

S Kumar, K K Dubey, S Tripathi, M Fujii, K Misra
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引用次数: 32

Abstract

Di-O-glycinoyl curcumin (I), di-O-glycinoyl-C4-glycyl-curcumin (II), 5'-deoxy-5'-curcuminyl thymidine (5'-cur-T) (III) and 2'-deoxy-2'-curcuminyl uridine (2'-cur-U) (IV) have been synthesized and characeterised by elemental analysis & 1H NMR. The antibacterial activities of these four bioconjugates has been tested particularly for multiresistant micro-organisms. Best results are shown by I & IV. These bioconjugates serve dual purpose of systemic delivery as well as therapeutic agents against viral diseases.

姜黄素生物偶联物的设计与合成以改善全身递送。
合成了二- o -甘氨酸基姜黄素(I)、二- o -甘氨酸基- c4 -甘氨酸基姜黄素(II)、5'-脱氧-5'-姜黄基胸苷(5'- curt) (III)和2'-脱氧-2'-姜黄基尿苷(2'- curu) (IV),并通过元素分析和1H NMR对其进行了表征。对这四种生物偶联物的抗菌活性进行了测试,特别是对多重耐药微生物的抗菌活性。I和IV显示出最好的效果。这些生物偶联物具有全身递送和治疗病毒性疾病的双重目的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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