Colonic drug delivery: an updated review.

AAPS PharmSci Pub Date : 2003-01-01 DOI:10.1208/ps050217
M Ajmal Shareef, Roop K Khar, Alka Ahuja, Farhan Jalees Ahmad, Swita Raghava
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引用次数: 0

Abstract

Specific targeting of drug to the colon is recognized to have several therapeutic advantages. Drugs that are destroyed by the acidic environment of the stomach or metabolized by pancreatic enzymes are only slightly affected in the colon. Sustained colonic delivery of drugs can be useful in the treatment of nocturnal asthma, angina, and arthritis. Treatment of colonic diseases such as ulcerative colitis, Crohn's disease, and colorectal cancer is more effective with direct delivery of drugs to the colon. This article is aimed at providing insight into the design considerations and evaluation of colonic drug delivery systems. The anatomy and physiology of the lower gastrointestinal tract is discussed; then the biopharmaceutical aspects are considered in relation to drug absorption in the colon. Various approaches to colon-specific drug delivery are discussed.

结肠给药:最新综述。
对结肠进行特异性靶向治疗被认为有几个治疗优势。被胃的酸性环境破坏或被胰酶代谢的药物在结肠中只受到轻微影响。持续结肠给药可用于治疗夜间哮喘、心绞痛和关节炎。治疗结肠疾病,如溃疡性结肠炎、克罗恩病和结直肠癌,直接将药物输送到结肠更有效。本文旨在提供深入了解结肠给药系统的设计考虑和评估。讨论了下消化道的解剖学和生理学;然后考虑与结肠中药物吸收有关的生物制药方面。讨论了结肠特异性药物递送的各种方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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