[Standard technique of oncologic colorectal surgery].

P Buchmann
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引用次数: 3

Abstract

Who ever is writing about standards should put himself the question: What is a standard? How is it produced? Who is defining it? How compulsory is it? A standard should only be understood as guiding principles or as following guidelines and never as a dogma, while otherwise every operative technical or therapeutical progress is prohibited. On the basis of the onco-surgical guidelines for the colo-rectal carcinoma is shown how standards can begin to sway. The Turnbull "no-touch isolation technique" does not stand up to the criteria of the evidence based medicine. The usefulness of the high ligation of the veins and the intestinal occlusion has not been proven by any studies. The central ligature of the Arteria mesenterica inferior in left resection is wrong according more recent anatomical knowledge. Ligation near to the aorta leads obligatory to lesions of the plexus hypogastricus. Animal experiments are controversial concerning the dissemination of tumour cells during crushing of the cancer. And a prospective controlled study does not show any advantage of respecting the Turnbull criteria. Independent prognostic factors are the surgeon, the frequency of performing the procedure in the hospital concerned, the pT and N stage, the R-0 resection and according to American pathologists the pre-operative CEA titre. Also are mentioned the infiltration of veins and lymph vessels, micro metastases in lymph nodes and the grading. The resection should if possible be performed in anatomical layers, specially considering the meso-rectum. What should be done in the distal 8 cm till the pelvic floor has not yet been clarified. On the contrary, the laparoscopic surgery has definitively also found its acceptance in oncological surgery. The discussions about port-metastases and tumour-cell-dissemination by the pneumoperitoneum-gas have silenced. Already, partially better long-term results are mentioned. In the beginning of 2003, the pillars of the standard technique of oncological colo-rectal surgery are besides the orthograde intestinal flushing, the pre-operative low molecular Heparin and the antibiotic prophylaxis, the open or laparoscopic R-0 en bloc resection, the minimal safety distance in the low rectum of 1 cm, the ligature of the Arteria mesenterica inferior 2-3 cm distally to its origin from the aorta in case of left resection, respectively the Arteria ilio-colica at its origin from the Arteria mesenterica superior in case of right resection, the cytotoxic intestinal flushing in case of left resection and the flushing of the abdominal cavity as well as the port-site with Taurolin 0.5%. In case of rectum-carcinoma uT3 or uN+, a neo-adjuvant radio-chemotherapy is administered and adjuvant chemotherapy is given by positive nodal colon-carcinoma.

【肿瘤结直肠手术标准技术】。
任何写标准的人都应该问自己一个问题:什么是标准?它是如何产生的?谁在定义它?它有多强制?标准只应被理解为指导原则或遵循指导方针,而不应被理解为教条,否则任何手术技术或治疗进展都是被禁止的。在结直肠癌肿瘤外科指南的基础上显示了标准是如何开始动摇的。特恩布尔的“无接触隔离技术”不符合循证医学的标准。静脉高位结扎和肠道闭塞的有效性尚未得到任何研究的证实。根据最近的解剖学知识,在左切除中,肠系膜动脉下方的中央结扎是错误的。主动脉附近的结扎会导致胃下肌丛的损伤。动物实验在肿瘤粉碎过程中肿瘤细胞的扩散存在争议。一项前瞻性对照研究并没有显示出遵守特恩布尔标准的任何优势。独立的预后因素包括外科医生、在相关医院进行手术的频率、pT和N期、R-0切除术以及美国病理学家认为的术前CEA滴度。并对静脉、淋巴管浸润、淋巴结微转移及分级进行了讨论。如果可能,切除应在解剖层进行,特别是考虑到直肠中系。在远端8厘米至骨盆底处应该做什么尚未明确。相反,腹腔镜手术在肿瘤手术中也得到了肯定的接受。关于肝转移和肿瘤细胞通过气腹气体播散的讨论已经沉默。已经提到了部分较好的长期结果。2003年开始,肿瘤结直肠手术标准技术的支柱除了正位肠冲洗,术前低分子肝素和抗生素预防,开放或腹腔镜R-0整体切除,低直肠1cm的最小安全距离,左切除时结扎肠系膜动脉离主动脉远端2-3 cm,分别为右切除时源自肠系膜上动脉的髂结肠动脉、左切除时源自肠系膜上动脉的细胞毒性肠道冲洗、0.5% Taurolin对腹腔及端口部位的冲洗。对于直肠癌uT3或uN+,给予新辅助放化疗,阳性结直肠癌给予辅助化疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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