Viral reservoirs an impediment to HAART: new strategies to eliminate HIV-1.

Nitin K Saksena, Da'ed N Haddad
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引用次数: 20

Abstract

The introduction of potent drug combinations comprising reverse transcriptase and protease inhibitors has dramatically altered the natural history of HIV disease, at least in the short term. Unfortunately, poor penetrability into different anatomic compartments, toxicity and drug resistance, are some of the problems related to their prolonged use. HIV's ability to mutate and become resistant along with the ongoing viral replication during HAART, which may lead to the emergence of independently evolving viral strains in different anatomic compartments and establishment of latent viral reservoirs also remain critical for the success and failure of antiretroviral therapy. Current drug therapies do not eliminate these viral reservoirs, nor do they discourage their formation. New strategies are needed for flushing hidden pockets of HIV in vivo. This review will focus mainly on novel strategies in the pipeline, along with the recent developments in the field.

病毒储存库是HAART的障碍:消除HIV-1的新策略。
引入含有逆转录酶和蛋白酶抑制剂的强效药物组合,至少在短期内显著改变了艾滋病毒疾病的自然史。不幸的是,对不同解剖腔室的渗透性差,毒性和耐药性,是与它们长期使用有关的一些问题。在HAART治疗过程中,随着病毒复制的进行,HIV发生突变并产生耐药性的能力可能导致不同解剖室中出现独立进化的病毒株,并建立潜伏病毒库,这对抗逆转录病毒治疗的成败也至关重要。目前的药物治疗不能消除这些病毒库,也不能阻止它们的形成。需要新的策略来清除体内隐藏的艾滋病毒。这篇综述将主要集中在管道中的新策略,以及该领域的最新发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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