Circular dichroism and the anomeric configuration of C-glycofuranosyl-2-phenyl-2H-1,2,3-triazoles.

Enantiomer Pub Date : 2002-11-01 DOI:10.1080/10242430215712
Mohammed A E Sallam
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引用次数: 5

Abstract

Circular dichroism spectra of a series of 4-(tetra-hydroxy-tetryl-1-yl)2-phenyl-2H-1,2,3-triazoles were measured and the sign of their Cotton effects was correlated to the absolute configuration of the hydroxyl group alpha to the triazole base moiety. Those having the D-glycero-configuration in their Fischer projection formula show positive Cotton effect and those with the L-glycero-configuration show negative Cotton effect. This correlation was extended for the assignment of the anomeric configuration of the corresponding glycofuranosyl-C-nucleosides.

c -糖呋喃基-2-苯基- 2h -1,2,3-三唑的圆二色性和异构构型。
测定了一系列4-(四羟基四基-1-基)2-苯基- 2h -1,2,3-三唑的圆二色光谱,发现它们的棉花效应与羟基α与三唑碱基部分的绝对构型有关。在Fischer投影公式中,具有d -甘油构型的人表现出正的棉花效应,而具有l -甘油构型的人则表现出负的棉花效应。这种相关性被扩展到相应的糖呋喃基- c核苷的端粒构型的分配。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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