[Study on GSTs activity in trinitrotoluene cataract].

Abstract

Objective: To direct the relationship between the activity of glutathione S-transferases(GSTs) and susceptibility to trinitrotoluene cataract (TC).

Methods: KMSL method was used to test the activity of GSTs in 154 cases of TC(group A), 41 cases of non-trinitrotolune cataract (group B), and 40 normal subjects (group B).

Results: The activity of GSTs in group TC was significantly lower than that in the two control groups (P < 0.01). The differences in GSTs activity were highly significant between the four stages of TC (P < 0.01), in which the sequence of GSTs activity levels from high to low was the stage of observation, stage I, stage II, and stage III. Compared to the persons with gst mu gene, the persons without gst mu gene had significantly lower GSTs activity (P < 0.01). It was found that the GSTs activity of the persons without gst mu gene in TC group was significantly lower than that of the persons without gst mu gene in the two control groups (P < 0.01), but the differences in GSTs activity between the persons with gst mu gene among the three groups were not significant (P > 0.05). The most noticeable correlation was observed between GSTs activity gst mu gene deletion (r = 0.702, P < 0.01).

Conclusion: TC and its stages are closely correlated with the activity of GSTs.