[The expression of collagen type I and type II during the second fracture healing].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao Pub Date : 2002-04-01

Xian Zhang, Fan Wang, Hongmei Jiang, Ruixiang Li

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Abstract

Objective: This study was conducted to disclose the rules of collagen type I and II production and hence to acquire knowledge about the mechanism of repairing during the second period of fracture healing.

Methods: An experimental model of second fracture healing at rat's femurs was used to study the production of collagen type I and II by means of immunohistochemistry; meanwhile the histologic changes were observed with the use of HE staining and Alcian blue staining at 3 days, 1, 2, 3, 4 weeks postoperatively.

Results: The expression of both collagen type I and II was detected by immunohistochemistry at 1 week. The peak expression of collagen type II occurred at 3 weeks. The higher expression of collagen type I was observed at 4 weeks.

Conclusion: The morphologic changes of chondrocyte and the production of collagen type I and II by chondrocyte in cartilage callus are correlated with their repairing function during different periods of fracture healing.

本刊更多论文

【第二次骨折愈合过程中ⅰ型和ⅱ型胶原蛋白的表达】。

目的:本研究旨在揭示I型和II型胶原蛋白的生成规律，从而了解骨折愈合第二阶段的修复机制。方法:采用大鼠股骨二次骨折愈合实验模型，采用免疫组化方法研究ⅰ型和ⅱ型胶原蛋白的生成;同时于术后3天、1、2、3、4周采用HE染色和阿利新蓝染色观察组织学变化。结果:1周免疫组化检测ⅰ型和ⅱ型胶原蛋白的表达。II型胶原蛋白的表达高峰出现在第3周。第4周时，I型胶原表达升高。结论:骨折愈合不同时期软骨组织软骨细胞形态变化及I型和II型胶原的生成与其修复功能相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao

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