{"title":"[Effects of testosterone on VEGF and FLK-1 protein expression in the ventral prostate of rat].","authors":"Xiaodong Liu, Qiang Dong, Yiping Lu, Bangliang Xiao, Xiuying Yang, Yuru Yang","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of testosterone on VEGF and FLK-1 protein expression in the ventral prostate of Rat.</p><p><strong>Method: </strong>SD rats were castrated, and 7 days later they were injected with different doses of testosterone. The histological changes were observed with the use of HE staining, and the protein expression of VEGF, FLK-1 were measured by immunohistochemical test.</p><p><strong>Results: </strong>In the normal ventral prostate, different growth forms of epithelium were observed. In the castrated group, the proteins of VEGF, FLK-1 were positive in growth active epithelium and vascular endothelium; the weight of prostate decreased (P < 0.05); the histological appearance was epithelial atrophy, and there was significantly decreased protein expression of VEGF, FLK-1 in the prostatic epithelium (P < 0.05). It was found that testosterone injection stimulated prostatic hyperplasia gradually The histological changes were epithelial progressive proliferation. And a gradually increased protein expression of VEGF, FLK-1 in the prostatic epithelium was detected (P < 0.05).</p><p><strong>Conclusion: </strong>Testosterone can stimulate prostatic growth probably by upregulating the protein expression of VEGF and FLK-1.</p>","PeriodicalId":13173,"journal":{"name":"Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao","volume":"33 2","pages":"226-8"},"PeriodicalIF":0.0000,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To investigate the effects of testosterone on VEGF and FLK-1 protein expression in the ventral prostate of Rat.
Method: SD rats were castrated, and 7 days later they were injected with different doses of testosterone. The histological changes were observed with the use of HE staining, and the protein expression of VEGF, FLK-1 were measured by immunohistochemical test.
Results: In the normal ventral prostate, different growth forms of epithelium were observed. In the castrated group, the proteins of VEGF, FLK-1 were positive in growth active epithelium and vascular endothelium; the weight of prostate decreased (P < 0.05); the histological appearance was epithelial atrophy, and there was significantly decreased protein expression of VEGF, FLK-1 in the prostatic epithelium (P < 0.05). It was found that testosterone injection stimulated prostatic hyperplasia gradually The histological changes were epithelial progressive proliferation. And a gradually increased protein expression of VEGF, FLK-1 in the prostatic epithelium was detected (P < 0.05).
Conclusion: Testosterone can stimulate prostatic growth probably by upregulating the protein expression of VEGF and FLK-1.
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