[A study of bone development and metabolism in childhood].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao Pub Date : 2001-12-01

M Liu, H Zheng, M Peng, L Liu, Z Peng, D Yang, J Shang, L Huang, L Suo

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Abstract

Objective: To explore the regularity of bone development and metabolism in childhood.

Methods: A survey was made to collect and analyze the data on bone biochemistry, the density of lumbar vertebrae and the X-ray examination of calcaneus in 224 healthy children aged 3-15 years in the urban area of Chengdu.

Results: Comparative analysis of serum and urine calcium and phosphate concentrations showed no significant difference between the age groups. The serum alkaline phosphatase (ALP) and bone alkaline phosphatase (BALP) were found to increase with age and reach their peak values in children aged 7-12 years, and their values were significantly higher than that of adults (P < 0.05). The density of lumbar vertebrae and the trabecular bone of calcanesus also developed with age.

Conclusion: The measurements of the bone biochemistry, bone density and the trabecular bone of calcaneus which reflect the bone development and metabolism have their special regularity in childhood. The criteria in use for adulthood is not fit for the evaluation in childhood. The data obtained can be used in clinical diagnosis and treatment of the bone metabolic diseases of children.

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[儿童骨骼发育和新陈代谢的研究]。

目的:探讨儿童骨发育与代谢的规律。方法:对成都市城区3 ~ 15岁健康儿童224例进行骨生化、腰椎密度及跟骨x线检查。结果:血清和尿液钙、磷酸盐浓度对比分析显示，两组间差异无统计学意义。血清碱性磷酸酶(ALP)和骨碱性磷酸酶(BALP)随年龄增长而升高，在7 ~ 12岁达到峰值，显著高于成人(P < 0.05)。腰椎和跟骨小梁的密度也随年龄增长而增加。结论:骨化学、骨密度和跟骨小梁的测量反映了儿童骨的发育和代谢有其特殊的规律。成人所用的标准不适用于儿童时期的评价。所得数据可用于儿童骨代谢性疾病的临床诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao

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