[Potential antimitotics. 2. Synthesis of 1-benzyl-3-carbethoxy-2-quinolones].

Abstract

A group of substituted 1-benzyl-3-carbethoxy-2-quinolones, whose design was based on the structures of well established antimitotics, were synthesized by a three reactions sequence. Although the yields of the first reaction (condensation of o-nitrobenzaldehydes with diethyl malonate) could not be improved, the synthetic route turned out quite efficient.