[A case of acute cholestatic hepatitis associated with Orlistat].

Doh Hyun Kim, Eun Hee Lee, Jae Chul Hwang, Jai Hak Jeung, Do Hyun Kim, Jae Youn Cheong, Sung Won Cho, Young Bae Kim
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Abstract

Orlistat(Xenical(R), Roche) is considered a safe and effective drug to treat obesity by reduced absorption of 30% digested fat. To date, no serious adverse effects affecting the liver have been published except a case of subacute hepatic failure leading to liver transplantation in a young women with moderate obesity treated with orlistat. We report a case of acute cholestatic hepatitis in a young woman with moderate obesity treated with orlistat: a 33-year-old female admitted for the evaluation of jaundice. Abdominal ultrasonography, ERCP, routine chemistry, viral markers, and a fine needle biopsy of liver were performed. Microscopic findings of the liver biopsy specimen were compatible with acute cholestatic hepatitis. After steroid therapy, liver function was improved.

奥利司他并发急性胆汁淤积性肝炎1例。
奥利司他(Xenical(R), Roche)被认为是一种安全有效的治疗肥胖的药物,通过减少30%的消化脂肪的吸收。迄今为止,除了一例接受奥利司他治疗的中度肥胖年轻女性出现亚急性肝功能衰竭导致肝移植外,未见严重的肝脏不良反应。我们报告一例急性胆汁淤积性肝炎的年轻女性与中度肥胖治疗奥利司他:一个33岁的女性入院评估黄疸。腹部超声检查、ERCP、常规化学检查、病毒标志物检查和肝脏细针活检。肝活检标本的显微镜检查结果与急性胆汁淤积性肝炎相符。经类固醇治疗,肝功能有所改善。
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