Obsessive compulsive disorder in huntington disease: a case of isolated obsessions successfully treated with sertraline.

Neuropsychiatry, neuropsychology, and behavioral neurology Pub Date : 2002-09-01

Tanja Patzold, Martin Brüne

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Abstract

Objective: To report about a patient with Huntington disease (HD) in combination with obsessions who was successfully treated with a selective serotonin reuptake inhibitor.

Background: Obsessive compulsive disorder (OCD) has rarely been reported in association with HD, and little is known about the treatment of patients with OCD symptoms and HD.

Methods: We describe a 42-year-old woman who experienced isolated obsessive thoughts about killing her neighbor 10 years after the onset of her genetically confirmed HD.

Results: Sertraline was prescribed at a daily dose of 150 mg with a complete remission of obsessive ideas within 4 weeks of treatment.

Conclusions: The basal ganglia are known to play an important role in the pathogenesis of OCD and HD. Thus, it is conceivable that a degeneration of the caudate nucleus as in HD may also account for obsessive and compulsive symptoms in this disorder. To our knowledge, this is the first report about a patient with HD in combination with obsessions alone who was successfully treated with a selective serotonin reuptake inhibitor. However, the association of OCD with HD warrants further systematic evaluation.

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亨廷顿病的强迫症:舍曲林成功治疗孤立性强迫症一例。

目的:报道一例亨廷顿病合并强迫症患者成功应用选择性血清素再摄取抑制剂治疗。背景:强迫症(OCD)与HD相关的报道很少，对强迫症和HD患者的治疗也知之甚少。方法:我们描述了一位42岁的女性，她在遗传确诊的HD发病10年后经历了杀死邻居的孤立强迫性想法。结果:舍曲林每日剂量150mg，治疗4周后强迫观念完全缓解。结论:基底神经节在强迫症和多动症的发病机制中起重要作用。因此，可以想象的是，HD的尾状核退化也可能是强迫症和强迫症状的原因。据我们所知，这是第一个用选择性血清素再摄取抑制剂成功治疗HD合并强迫症患者的报道。然而，强迫症与HD之间的关系需要进一步的系统评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neuropsychiatry, neuropsychology, and behavioral neurology

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