Studies of human motor physiology with transcranial magnetic stimulation.

Muscle & nerve. Supplement Pub Date : 2000-01-01 DOI:10.1002/1097-4598(2000)999:9<::aid-mus6>3.0.co;2-i

R Chen

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引用次数: 258

Abstract

Transcranial magnetic stimulation (TMS) is a safe, noninvasive, and painless way to stimulate the human motor cortex in behaving human subjects. When it is applied as a single-pulse, measurements such as central conduction time, motor threshold, silent-period duration, recruitment curve, and mapping of muscle representation can be determined. Paired-pulse TMS is a useful way to examine cortical excitability. Single and paired-pulse TMS have been applied to study plasticity following amputation and cortical excitability in patients with dystonia. Another form of TMS is repetitive TMS (rTMS), with stimuli delivered repeatedly to a single scalp site. High-frequency rTMS can be used to transiently inactivate different cortical areas to study their functions. rTMS can also modulate cortical excitability. At stimulus frequencies higher than 5 Hz, rTMS increases cortical excitability, and stimulation around 1 Hz reduces cortical excitability. Modulation of cortical excitability by rTMS has therapeutic potential in psychiatric and neurological disorders.

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经颅磁刺激对人体运动生理学的研究。

经颅磁刺激(TMS)是一种安全、无创、无痛的刺激人类运动皮层的方法。当它作为单脉冲应用时，可以确定诸如中枢传导时间，运动阈值，静默期持续时间，招募曲线和肌肉表征映射等测量值。配对脉冲经颅磁刺激是一种检测皮质兴奋性的有效方法。单脉冲和双脉冲经颅磁刺激已被应用于研究截肢后的可塑性和肌张力障碍患者的皮质兴奋性。另一种形式的经颅磁刺激是重复经颅磁刺激(rTMS)，反复向单个头皮部位传递刺激。高频rTMS可用于短暂灭活不同的皮质区域，以研究其功能。rTMS还可以调节皮质兴奋性。当刺激频率高于5hz时，rTMS增加皮层兴奋性，而1hz左右的刺激降低皮层兴奋性。通过rTMS调节皮质兴奋性在精神和神经疾病中具有治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Muscle & nerve. Supplement

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