No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family-based study of a Palestinian Arab population.

American Journal of Medical Genetics Pub Date : 2000-12-04

I Kremer, M Rietschel, M Dobrusin, M Mujaheed, I Murad, M Blanaru, I Bannoura, D J Müller, T G Schulze, A Reshef, S Gathas, S Schwab, D Wildenauer, R Bachner-Melman, R H Belmaker, W Maier, R P Ebstein

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Abstract

Several recent meta-analyses appear to show a weak but significant effect of both forms of the gly/ser DRD3 polymorphism in conferring risk for schizophrenia. Since most studies have employed the artifact-prone case-control design, we thought it worthwhile to examine the role of this polymorphism using a robust family-based strategy in an ethnic group not previously systematically studied in psychiatric genetics, Palestinian Arabs. We failed to obtain any evidence in 129 Palestinian triads, using the haplotype relative risk (allele frequency: Pearson chi-square = 0.009, P > 0.1, df = 1, n = 258 alleles) or transmission disequilibrium test design (chi-square = 0.38, P > 0.1, n = 86 families) for association/linkage (or increased homozygosity) of the DRD3 Bal I polymorphism to schizophrenia in our sample. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:778-780, 2000.

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在巴勒斯坦阿拉伯人群的家庭研究中，多巴胺D3受体Bal I多态性与精神分裂症之间没有关联。

最近的几项荟萃分析似乎显示，两种形式的gly/ser DRD3多态性在赋予精神分裂症风险方面都有微弱但显著的影响。由于大多数研究都采用了容易产生伪象的病例对照设计，我们认为在一个以前没有在精神遗传学中系统研究过的民族——巴勒斯坦阿拉伯人中，使用一个强大的基于家庭的策略来检查这种多态性的作用是值得的。我们使用单倍型相对风险(等位基因频率:Pearson卡方= 0.009,P > 0.1, df = 1, n = 258个等位基因)或传播不平衡检验设计(卡方= 0.38,P > 0.1, n = 86个家族)来检测我们样本中DRD3 Bal I多态性与精神分裂症的关联/连锁(或增加的纯合性)，但未能在129个巴勒斯坦三联体中获得任何证据。点。J. Med. Genet。(Neuropsychiatr。[热][j] . 96:778- 780,2000。

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American Journal of Medical Genetics

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