Molecular characteristics of phosphate transporters and their regulation.

N Hernando, I C Forster, J Biber, H Murer
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引用次数: 21

Abstract

A key process in overall P(i)-homeostasis is renal proximal tubular reabsorption of inorganic phosphate (P(i)), which involves secondary active sodium/phosphate (Na(+)/P(i)) cotransport reabsorption at the brush border membrane. Among the two different molecularly identified Na(+)/P(i) cotransporters, the type-IIa Na(+)/P(i) cotransporter (NaPi-IIa) accounts for up to 70% of brush border membrane transport. Regulation of renal P(i) reabsorption centers around brush border membrane insertion and retrieval of transporter protein under the influence of hormonal and nonhormonal factors. Immunohistochemical and fluorescence techniques have provided new insights into the tissue distribution and the regulation processes. The intrinsic electrogenicity of NaPi-IIa, has allowed detailed studies of the transport kinetics of NaPi-IIa and, combined with mutagenesis methods, structure-function information at the protein level is emerging.

磷酸转运体的分子特性及其调控。
整体P(i)-稳态的一个关键过程是肾近端小管对无机磷酸盐(P(i))的重吸收,这涉及到刷状边界膜的次级活性钠/磷酸盐(Na(+)/P(i))共转运重吸收。在两种不同分子鉴定的Na(+)/P(i)共转运体中,iia型Na(+)/P(i)共转运体(NaPi-IIa)占刷状边界膜运输的70%。在激素和非激素因素的影响下,肾P(i)重吸收的调控主要围绕刷状边界膜的插入和转运蛋白的回收。免疫组织化学和荧光技术为研究组织分布和调控过程提供了新的见解。NaPi-IIa固有的电原性,使得对NaPi-IIa转运动力学的详细研究成为可能,并且结合诱变方法,在蛋白质水平上的结构-功能信息正在出现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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