From the growth cone surface to the cytoskeleton: one journey, many paths.

Journal of neurobiology Pub Date : 2000-08-01
C A Korey, D Van Vactor
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引用次数: 0

Abstract

The mechanisms that guide axons through a complex cellular landscape to reach appropriate target cells are central to our understanding of neural development. Decades of work suggest that guidance information is interpreted by signaling machinery that controls the complex and dynamic cytoskeleton at the growth cone leading edge. Recent insights from the areas of signal transduction and cell biology have identified a number of key components that play central roles in this chain of command, including members of the Ena/VASP and WASP family of proteins. Although our understanding of the precise mechanism by which these proteins control actin assembly is still incomplete, these players are emerging as potential sites of integration that translate convergent signals into directional cell movement. This brief review explores some of the most recent articles on this topic.

从生长锥表面到细胞骨架:一次旅程,多条路径。
引导轴突通过复杂的细胞景观到达适当的靶细胞的机制是我们理解神经发育的核心。几十年的研究表明,引导信息是通过控制生长锥前缘复杂和动态的细胞骨架的信号机制来解释的。最近来自信号转导和细胞生物学领域的见解已经确定了许多在这一指挥链中发挥核心作用的关键成分,包括Ena/VASP和WASP家族蛋白的成员。虽然我们对这些蛋白质控制肌动蛋白组装的确切机制的理解仍然不完整,但这些参与者正在成为将趋同信号转化为定向细胞运动的潜在整合位点。这篇简短的综述探讨了关于这个主题的一些最新文章。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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