The multiple decisions made by growth cones of RGCs as they navigate from the retina to the tectum in Xenopus embryos.

Journal of neurobiology Pub Date : 2000-08-01
K S Dingwell, C E Holt, W A Harris
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引用次数: 0

Abstract

Retinal ganglion cells (RGCs) of Xenopus laevis send axons along a stereospecific pathway from the retina to their target the optic tectum. Viewed from the point of the growth cone, this journey is reflected by discrete processes of axon initiation, axon outgrowth, navigation, target recognition, and innervation. These processes are characterised by distinct signalling mechanisms that trigger dynamic changes in growth cone morphology and behavior. Here we review work primarily from our laboratory, examining these events from a cellular and molecular perspective, focusing on the roles of FGFs, netrins, receptors, and intracellular effectors.

爪蟾胚胎中RGCs的生长锥在从视网膜到顶盖的过程中所做的多个决定。
非洲爪蟾的视网膜神经节细胞(RGCs)将轴突沿立体特异性途径从视网膜发送到其目标视觉顶盖。从生长锥的角度来看,这一过程反映在轴突起始、轴突生长、导航、目标识别和神经支配的离散过程中。这些过程的特点是不同的信号机制,触发生长锥形态和行为的动态变化。在这里,我们主要回顾我们实验室的工作,从细胞和分子的角度研究这些事件,重点关注FGFs、网络蛋白、受体和细胞内效应器的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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