L Y Hu, T R Ryder, M F Rafferty, K M Siebers, T Malone, A Chatterjee, M R Feng, S M Lotarski, D M Rock, S J Stoehr, C P Taylor, M L Weber, G P Miljanich, E Millerman, B G Szoke
{"title":"Neuronal N-type calcium channel blockers: a series of 4-piperidinylaniline analogs with analgesic activity.","authors":"L Y Hu, T R Ryder, M F Rafferty, K M Siebers, T Malone, A Chatterjee, M R Feng, S M Lotarski, D M Rock, S J Stoehr, C P Taylor, M L Weber, G P Miljanich, E Millerman, B G Szoke","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Several novel N-type voltage sensitive calcium channel blockers showed high affinity in the IMR32 assay and efficacy in the anti-writhing model. Herein, we describe the design, synthesis, SAR studies, biological data, physicochemical properties and pharmacokinetics of this 4-piperidinylaniline series.</p>","PeriodicalId":11297,"journal":{"name":"Drug design and discovery","volume":"17 1","pages":"85-93"},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug design and discovery","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Several novel N-type voltage sensitive calcium channel blockers showed high affinity in the IMR32 assay and efficacy in the anti-writhing model. Herein, we describe the design, synthesis, SAR studies, biological data, physicochemical properties and pharmacokinetics of this 4-piperidinylaniline series.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
