The actions of crustacean cardioactive peptide on adult and developing stomatogastric ganglion motor patterns.

Journal of neurobiology Pub Date : 2000-07-01
K S Richards, E Marder
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Abstract

The motor patterns produced by the stomatogastric ganglion (STG) are strongly influenced by descending modulatory inputs from anterior ganglia. With these inputs intact, in control saline, the motor patterns produced by the stomatogastric nervous system of embryonic and larval lobsters are slower and less regular than those of adult lobsters. We studied the effects of the hormonal modulator, crustacean cardioactive peptide (CCAP) on the discharge patterns of STG motor patterns in embryos, larvae, and adult Maine lobsters, Homarus americanus, with the anterior inputs present and absent. In adults, CCAP initiated robust pyloric rhythms from STGs isolated from their descending control and modulatory inputs. Likewise, CCAP initiated robust activity in isolated embryonic and larval STGs. Nonetheless, quantitative analyses revealed that the frequency and regularity of the STG motor neuron discharge seen in the presence of CCAP in isolated STGs from embryos were significantly lower than those seen late in larval life and in adults under the same conditions. In contrast, when the descending control and modulatory pathways to the STG were left intact, the embryonic and larval burst frequency seen in the presence of CCAP was increased by CCAP, whereas the burst frequency in adults was decreased by CCAP, so that in CCAP the frequencies at all stages were statistically indistinguishable. These data argue that immature embryonic motor patterns seen in the absence of CCAP are a function of immaturity in both the STG and in the descending and modulatory pathways.

甲壳类动物促心肽对成人及发育中的口胃神经节运动模式的影响。
口胃神经节(STG)产生的运动模式受到来自前神经节的下行调节输入的强烈影响。在这些输入完整的情况下,在对照盐水中,胚胎和幼虾的口胃神经系统产生的运动模式比成年龙虾慢,也不那么规律。我们研究了激素调节剂甲壳类心脏活性肽(CCAP)对胚胎、幼虫和成年缅因龙虾(Homarus americanus) STG运动模式放电模式的影响,其中前输入存在和不存在。在成人中,CCAP启动了与下行控制和调节输入分离的stg的强大幽门节律。同样,CCAP在离体胚胎和幼虫STGs中启动了强大的活性。尽管如此,定量分析显示,在CCAP存在的情况下,胚胎中分离的STG运动神经元放电的频率和规律性明显低于幼虫后期和相同条件下的成虫。相反,当对STG的下行控制和调节通路保持完整时,CCAP存在时,胚胎和幼虫的爆发频率增加,而成虫的爆发频率减少,因此在CCAP中,所有阶段的频率在统计学上没有区别。这些数据表明,在没有CCAP的情况下,未成熟的胚胎运动模式是STG和下行和调节通路不成熟的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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