S J Bucknell, M Mohajeri, J Low, M McDonald, D G Hill
{"title":"Single-versus multiple-dose antibiotics prophylaxis for cardiac surgery.","authors":"S J Bucknell, M Mohajeri, J Low, M McDonald, D G Hill","doi":"10.1046/j.1440-1622.2000.01837.x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study was carried out to determine if single-dose antimicrobial prophylaxis is sufficient for cardiac surgery.</p><p><strong>Methods: </strong>The study was a prospective non-randomized trial of 353 consecutive patients undergoing cardiac surgery. Group A (n = 151) received 48 h of prophylaxis and Group B (n = 202) received a single dose. Cephazolin was used in all patients except those at high risk from methicillin-resistant Staphylococcus aureus (MRSA) who received teicoplanin and timentin.</p><p><strong>Results: </strong>There was an overall in-hospital infection rate of 2.8%. There was no significant difference in rate or type of infection between the two groups.</p><p><strong>Conclusions: </strong>An in-hospital infection rate of 2.8% compares favourably with other reported series. Single-dose antimicrobial prophylaxis is as effective as a 48-h regimen. Targeting high-risk groups is effective.</p>","PeriodicalId":22494,"journal":{"name":"The Australian and New Zealand journal of surgery","volume":"70 6","pages":"409-11"},"PeriodicalIF":0.0000,"publicationDate":"2000-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1440-1622.2000.01837.x","citationCount":"50","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Australian and New Zealand journal of surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1046/j.1440-1622.2000.01837.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 50
Abstract
Background: This study was carried out to determine if single-dose antimicrobial prophylaxis is sufficient for cardiac surgery.
Methods: The study was a prospective non-randomized trial of 353 consecutive patients undergoing cardiac surgery. Group A (n = 151) received 48 h of prophylaxis and Group B (n = 202) received a single dose. Cephazolin was used in all patients except those at high risk from methicillin-resistant Staphylococcus aureus (MRSA) who received teicoplanin and timentin.
Results: There was an overall in-hospital infection rate of 2.8%. There was no significant difference in rate or type of infection between the two groups.
Conclusions: An in-hospital infection rate of 2.8% compares favourably with other reported series. Single-dose antimicrobial prophylaxis is as effective as a 48-h regimen. Targeting high-risk groups is effective.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
