[Lupus anticoagulant: complete automation (ACL-Futura) and diagnostic algorithm].

Sangre Pub Date : 1999-12-01

C Aulesa, J Tusell, J J Ortega, M Sentis

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Abstract

Purpose: The technical and clinical evaluation of a new laboratory profile with six tests, for the realization of the assay called "lupic anticoagulant" with the help of ACL-Futura analyzer (Intrumentation Laboratory).

Results: The within-between day imprecision of the tests that compose the profile: APTT-Diluted, APTT-D Mix, LacScreen, LacScreen Mix, LacConfirm and LacConfirm Mix, are between 2.87%-11.61% with controls, this imprecision is lowest with patients. A study of bilirrubin and lipemia interferences is presented. The practicability study present the technical, time consuming difficulty, and shows that the cost of the screening test is about 1136 ptas (6.83 euros) and with the confirmative test is 2766 ptas (16.62 euros). The clinical study describes our preliminary results with the application of this new profile for almost 2 years and six clinical cases are presented.

Conclusions: The good technical and clinical results of the evaluation of the new profile proposed to detect the positive lupic anticoagulant, in addition to the fully automated assay with the ACL-Futura analyzer, validate the whole method to resolve the increased demand of these parameters.

本刊更多论文

狼疮抗凝剂:完全自动化(ACL-Futura)和诊断算法。

目的:利用ACL-Futura分析仪(仪器实验室)实现“狼疮抗凝血”检测，对一种包含6项检测的新型实验室结构进行技术和临床评价。结果:由aptt -稀释、APTT-D混合、LacScreen、LacScreen混合、LacConfirm和LacConfirm混合组成的检测在对照组的日间不精确性在2.87%-11.61%之间，患者的不精确性最低。一项研究胆红素和血脂的干扰提出。可行性研究显示，筛选试验的成本约为1136 ptas(6.83欧元)，确认试验的成本为2766 ptas(16.62欧元)。临床研究描述了我们的初步结果与应用这种新的轮廓近2年，并提出了6个临床病例。结论:对新提出的检测红斑狼斑抗凝血阳性的谱图进行了良好的技术和临床评价，再加上采用ACL-Futura分析仪进行全自动检测，验证了整个方法解决了对这些参数需求增加的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sangre

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