The α1a and α1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action

Abstract

In this chapter we summarize some aspects of the structure-functional relationship of the α1a and α1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the α1a and α1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.