Biochemistry and pharmacology of aminoglycoside-induced hearing loss.

J Schacht
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Abstract

Discovered in the 1940s, the aminoglycoside antibiotics were the long-sought remedy for tuberculosis and other serious bacterial infections. They are still one of the most commonly used antibiotics today, thanks to the combination of their high efficacy with low cost. This review begins by addressing some of the history and the acute side effects of aminoglycosides. It then details their chronic toxicity to the inner ear (ototoxicity). The review concludes with recent advances that have demonstrated free-radical reactions as the underlying mechanism and intervention with antioxidant/chelation therapy to prevent aminoglycoside ototoxicity.

氨基糖苷性听力损失的生物化学和药理学研究。
氨基糖苷类抗生素发现于20世纪40年代,是人们长期寻求的治疗结核病和其他严重细菌感染的药物。由于其高效率和低成本的结合,它们仍然是当今最常用的抗生素之一。本文首先介绍氨基糖苷类药物的一些历史和急性副作用。然后详细介绍了它们对内耳的慢性毒性(耳毒性)。本文总结了最近的研究进展,证明自由基反应是潜在的机制,并通过抗氧化/螯合治疗干预来预防氨基糖苷耳毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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