The serotonin paradox: drug-receptor interaction in rat vas deferens.

Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia Pub Date : 1999-01-01

A Jurkiewicz, L G do Carmo, M H Yomura, N H Jurkiewicz

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Abstract

The contractile effect of serotonin was studied in rat vas deferens, in comparison with that of noradrenaline and tyramine, after reserpine treatment, surgical denervation, and transplantation to the colon. In reserpinized animals the effect of 5HT resembled that of tyramine, since it was strikingly reduced, in spite of a small residual effect, showing that in normal preparations the effects of 5HT and tyramine are predominantly due to the release of endogenous noradrenaline. However, in denervated or transplanted vas deferens, in which the effect of tyramine is also abolished, the effect of 5HT was potentiated. It is suggested that after chronic, long lasting depletion of endogenous noradrenaline, there are alternate mechanisms that are generated to improve the contractile effect of 5HT, but not of tyramine. The nature of these mechanisms is still unknown.

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血清素悖论:大鼠输精管中药物受体的相互作用。

研究了大鼠输精管在利血平治疗、手术去神经和结肠移植后血清素与去甲肾上腺素和酪胺的收缩作用。在利血平化的动物中，5HT的作用与酪胺相似，尽管残留效应很小，但效果显著降低，这表明在正常制剂中，5HT和酪胺的作用主要是由于内源性去甲肾上腺素的释放。然而，在去神经输精管或移植输精管中，酪胺的作用也被消除，5HT的作用被增强。这表明，内源性去甲肾上腺素长期消耗后，会产生其他机制来改善5HT的收缩作用，而不是酪胺。这些机制的性质尚不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia

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