Genetic risk assessment in hookah smokers.

Cytobios Pub Date : 2000-01-01

J S Yadav, S Thakur

引用次数: 0

Abstract

The genotoxic effect of hookah smoke was investigated on somatic chromosomes of 35 occupationally nonexposed male hookah smokers. These were compared with an equal number of nonsmokers matched with respect to age, sex, drug intake, if any, and socio-economic status. The mitotic index (MI), chromosomal aberrations (CA), sister chromatid exchanges (SCE) and satellite associations (SA) were analysed. All the parameters showed a significant increase (p < 0.01) in the smokers compared with control individuals, viz MI, 3.88-5.41; CA, 0.94-2.22; SCE, 3.59-5.66; and SA, 5.2-8.65. A distinct time and dose effect relationship was observed. Hookah smoke is thus, both clastogenic and genotoxic for human beings.

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水烟吸食者的遗传风险评估。

研究人员调查了水烟烟雾对 35 名未接触水烟职业的男性体细胞染色体的遗传毒性影响。这些人与同等数量的在年龄、性别、药物摄入量（如有）和社会经济地位方面相匹配的非吸烟者进行了比较。对有丝分裂指数（MI）、染色体畸变（CA）、姐妹染色单体交换（SCE）和卫星关联（SA）进行了分析。与对照组相比，吸烟者的有丝分裂指数（MI，3.88-5.41）、染色体畸变（CA，0.94-2.22）、姐妹染色单体交换（SCE，3.59-5.66）和卫星联会（SA，5.2-8.65）等所有参数都有明显增加（p < 0.01）。观察到了明显的时间和剂量效应关系。因此，胡卡烟对人类具有致畸性和遗传毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytobios

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