Separate and combined effects of a benzodiazepine (alprazolam) and noise on auditory brainstem responses in man.

Audiology : official organ of the International Society of Audiology Pub Date : 1999-11-01 DOI:10.3109/00206099909073042

J Parrot, J C Petiot, S Morizot, M T Petiot, H J Smolik

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Abstract

Auditory brainstem responses (ABRs) were recorded in 60 male or female, anxious or anxiety-free university students, before and after separated or simultaneous intake of alprazolam and exposure to noise. A significant increase of the latencies of the ABRs was found when subjects took alprazolam. This effect is consistent with the presence of gamma-aminobutyric acid (GABA), one of the neurotransmitters at terminals of cochlear efferent fibres A significant increase of the latencies was observed after noise alone. In subjects taking alprazolam when they are exposed to noise, the effect of noise on the ABR latencies is reduced, but not abolished. The effects of alprazolam on the ABR are consistent with the presence of GABA in the medulla and pons. Significant effects of noise upon III-V and I-V intervals suggest that auditory 'fatigue' may involve a retrocochlear component. Differences due to sex appear to be abolished by anxiety.

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苯二氮卓类药物(阿普唑仑)和噪音对人听觉脑干反应的单独和联合影响。

本文记录了60名焦虑或无焦虑的大学生在分别或同时摄入阿普唑仑和暴露于噪音前后的听觉脑干反应(ABRs)。当受试者服用阿普唑仑时，发现abr的潜伏期显著增加。这种效应与γ -氨基丁酸(GABA)的存在是一致的，GABA是耳蜗传出纤维末端的一种神经递质。在服用阿普唑仑的受试者中，当他们暴露于噪音时，噪音对ABR潜伏期的影响减弱，但没有消除。阿普唑仑对ABR的影响与脑髓和脑桥中GABA的存在一致。噪声对III-V和I-V音程的显著影响表明听觉“疲劳”可能涉及耳蜗后成分。性别差异似乎被焦虑所消除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Audiology : official organ of the International Society of Audiology

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