[Pulmonary valvuloplasty. Long term results at the Centro Medico la Raza].

J L Lázaro Castillo, J Munayer Calderón, T Aldana Pérez, R San Luis Miranda, G Maza Juárez, H Ramírez Reyes, L Roberto Quintero, L Arias Monroy, A Campos Gómez
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Abstract

The purpose of this study was to evaluate the immediate and long term results of pulmonary valve ballon dilation, and to determine the prognostic factors of failure in 109 patients (60 female and 49 male), aged 7.04 +/- 8.4 years. Seventy two patients (66.1%) had isolated valvular stenosis and 33.9% presented associated lesions. Peak systolic pressure gradient across the pulmonary valve decreased from 89.53 +/- 37.23 to 20.8 +/- 19.41 mmHg (p < 0.0001) after valvuloplasty. Forty three patients developed reactive infundibular stenosis after valvuloplasty with a systolic gradient of 19.65 +/- 35.64 mmHg. At a mean period of 8 years of follow-up the pressure gradient was 20.75 +/- 14.32 (p < 0.001). Valvuloplasty was successful in 86.2% of the cases with a global mortality of 1.9%, minor complications in 15.2%, and a failure rate of 13.8%. At follow-up restenosis developed in 6.7%. The comparative analysis between the groups of success and failure yield as significant risk factors for failure an age younger than 3.5 years and a pulmonary valve with displastic (p < 0.05) or combined morphology (p < 0.05). This group had also more complications and higher systolic gradients and right ventricular pressures post-dilation (p < 0.05). Pulmonary valvuloplasty is a safe and effective procedure for the treatment of pulmonary valve stenosis with a good immediate and long-term results, and is now considered the treatment of choice.

(肺动脉瓣膜成形术。拉扎医疗中心的长期研究结果。
本研究的目的是评估109例患者(女性60例,男性49例)肺瓣膜球囊扩张术的近期和长期效果,并确定失败的预后因素,年龄7.04±8.4岁。72例(66.1%)有孤立性瓣膜狭窄,33.9%有相关病变。瓣膜成形术后,肺动脉瓣的峰值收缩压梯度从89.53 +/- 37.23降至20.8 +/- 19.41 mmHg (p < 0.0001)。43例患者在瓣膜成形术后出现反应性小管狭窄,收缩梯度为19.65 +/- 35.64 mmHg。在平均8年的随访期间,压力梯度为20.75±14.32 (p < 0.001)。瓣膜成形术成功率为86.2%,总体死亡率为1.9%,轻微并发症发生率为15.2%,失败率为13.8%。随访时再狭窄发生率为6.7%。年龄小于3.5岁、肺瓣发育不全(p < 0.05)或合并形态(p < 0.05)为肺瓣失败的显著危险因素,成功组与失败组比较分析。术后并发症较多,舒张后收缩梯度和右心室压增高(p < 0.05)。肺动脉瓣成形术是一种安全有效的治疗肺动脉瓣狭窄的方法,具有良好的近期和长期效果,目前被认为是治疗的首选。
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