The effect of strength training on estimates of mitochondrial density and distribution throughout muscle fibres.

P D Chilibeck, D G Syrotuik, G J Bell
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引用次数: 61

Abstract

The purpose of this study was to investigate the effect of strength training (12 weeks, 3 days/week, four lower-body exercises) of young individuals (mean age 23.6 years) on estimates of mitochondrial distribution throughout muscle fibres. A control group (mean age 21. 7 years) was followed simultaneously. Skeletal muscle biopsy samples were obtained from the vastus lateralis, pre- and post-training. The regional distribution of subsarcolemmal and intermyofibrillar mitochondrial populations was determined using quantitative histochemical staining of succinate dehydrogenase (SDH) in type I and II muscle fibres. Strength training resulted in significant increases of 26% and 28% in the cross-sectional area of type I and II fibres, respectively (P < 0.05). Overall SDH activity decreased by 13% with strength training (P < 0.05). The decrease in SDH activity with strength training between fibre types and between subsarcolemmal and intermyofibrillar regions of muscle fibres was not different. Fibre area and SDH activity was unchanged in the control group. We conclude that the muscle hypertrophy associated with strength training results in reduced density of regionally distributed mitochondria, as indicated by the reduction in the activity of SDH.

力量训练对肌纤维中线粒体密度和分布的影响。
本研究的目的是调查年轻人(平均年龄23.6岁)的力量训练(12周,每周3天,4次下半身运动)对肌纤维中线粒体分布的影响。对照组(平均年龄21岁)。7年)同时随访。在训练前后分别从股外侧肌获得骨骼肌活检样本。采用I型和II型肌纤维中琥珀酸脱氢酶(SDH)的定量组织化学染色确定肌层下和肌纤维间线粒体群体的区域分布。力量训练导致I型和II型纤维横截面积分别显著增加26%和28% (P < 0.05)。力量训练使SDH活性降低13% (P < 0.05)。肌纤维类型之间以及肌纤维的肌上皮下和肌纤维间区域之间的力量训练对SDH活性的降低没有差异。对照组的纤维面积和SDH活性没有变化。我们得出结论,与力量训练相关的肌肉肥大导致区域分布的线粒体密度降低,正如SDH活性降低所表明的那样。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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