Outcome evaluation of early discharge of asthmatic children from hospital: A randomized control trial

MO Stormon1 MBBS, FRACP, CM MELLIS, PP VAN Asperen, HA Kilham
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引用次数: 16

Abstract The objective of our study was to compare the safety and efficacy of discharging asthmatic children from hospital on three versus four hourly nebulized salbutamol. The setting was a tertiary referral paediatric hospital in Sydney, NSW, Australia. The design was a randomized controlled parallel group study. All children admitted to hospital with acute asthma and who were over 18 months of age were eligible to enter the study. Patients were excluded if they had non-English speaking parents, no telephone, or chronic cardiac or neurological disease. Children were treated according to standard asthma management but were randomly allocated to be discharged on three or four hourly nebulized salbutamol. Patients were surveyed using a telephone questionnaire 1 to 2 weeks after discharge. The primary outcome measure was re-presentation to the Emergency Department (ED) within 7 days. Other outcomes included readmission to hospital, re-presentation to the local doctor, parental satisfaction and length of hospital stay. A total of 63 children were enrolled in the study (32 in the three hourly group and 31 in the four hourly group). There were no re-presentations to the ED or hospital readmissions within 1 to 2 weeks in either group. However, re-presentations to the local doctor were common, 71.8% in the three hourly and 74.1% in the four hourly groups, respectively. These were predominantly for routine review. The mean (± SD) hospital length of stay was not significantly different between the three and four hourly groups, 48.94 (± 20.61) and 54.88 (± 32.59) hours, respectively (P = 0.672). Parents felt the timing of discharge was ‘too early’ in five (15.6%) of three hourly and five (16.1%) of four hourly patients. Three (9.7%) of the four hourly but none of the three hourly patients felt they were sent home ‘later than necessary’. Five (15.1%) of the three hourly and three (9.7%) of the four hourly group parents did not feel comfortable looking after their child at home immediately after discharge. None of these differences were statistically significant. Discharge of asthmatic children from hospital on three hourly nebulized salbutamol is as safe and effective as on four hourly. Parents are generally very satisfied with timing of discharge, irrespective of frequency of nebulization. Earlier discharge benefits both the child and their family, and improves hospital bed utilization.

哮喘患儿早期出院的结局评价:一项随机对照试验
摘要:本研究的目的是比较哮喘患儿每小时雾化沙丁胺醇3次和每小时雾化沙丁胺醇4次的安全性和有效性。实验地点是澳大利亚新南威尔士州悉尼的一家三级转诊儿科医院。设计为随机对照平行组研究。所有因急性哮喘住院且年龄超过18个月的儿童都有资格进入这项研究。如果患者的父母不讲英语,没有电话,或患有慢性心脏或神经疾病,则排除在外。儿童按照标准哮喘管理进行治疗,但随机分配到每小时雾化三或四次沙丁胺醇出院。出院后1 ~ 2周采用电话问卷对患者进行调查。主要结局指标是7天内再次出现在急诊科(ED)。其他结果包括再入院、再次向当地医生就诊、父母满意度和住院时间。共有63名儿童参加了这项研究(32名在3小时组,31名在4小时组)。两组患者均未在1 ~ 2周内再次出现急诊科或再次入院。然而,再次向本地医生求诊的情况很常见,每小时3次的占71.8%,每小时4次的占74.1%。这些主要用于例行审查。3小时组和4小时组的平均住院时间(±SD)差异无统计学意义,分别为48.94(±20.61)小时和54.88(±32.59)小时(P = 0.672)。在每3小时就诊的患者中,有5名家长(15.6%)认为出院时间“太早”,在每4小时就诊的患者中,有5名家长(16.1%)认为出院时间“太早”。在4个小时就诊的病人中,有3个(9.7%)认为他们被“比必要的时间晚”送回家。三小时组中有五名(15.1%)和四小时组中有三名(9.7%)的父母在孩子出院后立即在家照顾他们感到不舒服。这些差异都没有统计学意义。哮喘患儿出院时每小时喷喷沙丁胺醇与每小时喷喷沙丁胺醇一样安全有效。无论雾化频率如何,家长通常对出院时间非常满意。尽早出院对儿童及其家庭都有好处,并提高医院病床的利用率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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