Expression of N-acetyl galactosaminylated and sialylated glycans by metastases arising from primary breast cancer.

S A Brooks, A J Leathem
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引用次数: 28

Abstract

This study examines the Helix pomatia lectin (HPA) binding characteristics of metastases arising from primary breast cancer, and compares HPA binding patterns with binding of Dolichos biflorus lectin (DBA), Limax flavus lectin (LFA), and a monoclonal antibody against the Tn epitope. Of 81 blocks of metastases in a range of tissues, taken at autopsy from 46 individuals, 79% were HPA positive. No site specificity with regard to HPA binding was observed. Both HPA-positive and -negative tumour deposits were seen within a single individual. HPA-positive tumours were commonly negative for binding of sialic acid specific lectin LFA (86% were negative). Binding patterns of alpha-GalNAc specific HPA and DBA, and a monoclonal antibody against Tn epitope (GalNAc-O-Ser/Thr) were markedly different.

n -乙酰半乳糖氨基化和唾液化聚糖在原发性乳腺癌转移中的表达。
本研究探讨了原发性乳腺癌转移灶中双螺旋pomatia凝集素(HPA)的结合特征,并将HPA的结合模式与Dolichos biflorus凝集素(DBA)、Limax flavus凝集素(LFA)和一种针对Tn表位的单克隆抗体的结合模式进行了比较。在46个人的尸检中,81块转移灶在一系列组织中,79%是HPA阳性。没有观察到HPA结合的位点特异性。hpa阳性和阴性肿瘤沉积均见于单个个体。hpa阳性肿瘤通常对唾液酸特异性凝集素LFA的结合呈阴性(86%为阴性)。α - galnac特异性HPA和DBA的结合模式以及针对Tn表位(GalNAc-O-Ser/Thr)的单克隆抗体存在显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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