M B Gottikh, E M Volkov, E A Romanova, T S Oretskaya, Z A Shabarova
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引用次数: 3
Abstract
This investigation is devoted to design of short "switch" oligonucleotides mono- or bi-functionnalized with intercalating agents capable to form a stable triplex with HIV integrase-cognate sequences and inhibit selectively HIV integration. Methods of intercalator incorporation at 5'- and/or 3'-terminal positions or one of the pyrimidine heterocyclic bases are developed.
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