Synthesis of modified thiopurine nucleosides for structural characterization of human thiopurine S-methyltransferase.

G A Korshunova, E Y Krynetski, M T Mtchedlidze, D V Agapkin, W E Evans, N F Krynetskaia
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引用次数: 2

Abstract

Synthesis of a number of photoactive thiopurine-containing nucleosides was described. S-methylation of the synthesized compounds in the course of the reaction catalyzed by recombinant human thiopurine S-methyltransferase was studied by UV-spectroscopy.

人硫嘌呤s -甲基转移酶结构表征的修饰硫嘌呤核苷的合成。
介绍了几种光活性含硫嘌呤核苷的合成。利用紫外光谱研究了重组人硫嘌呤s -甲基转移酶催化反应过程中合成化合物的s -甲基化。
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