[Protective role of endogenous nitric oxide to microcirculation of rats during burn shock].

Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns Pub Date : 1998-05-01

S Shi, K Wu

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Abstract

Objective: To investigate the role of nitric oxide (NO) in burn shock.

Methods: A model of 40% TBSA deep II burn injury in rats was used. The effects of L-NAME, the inhibitor of NO synthase, and L-Arg, the precursor of NO synthesis, on the mean arterial pressure (MAP), microcirculation of muscle, concentration of NO2(-)/NO3(-) in plasma and the survival time of animals were observed.

Results: The results showed that the synthesis of nitric oxide was increased significantly, accompanied with the decrease of MAP and the disturbances of microcirculation of muscle after burn. L-NAME inhibited the decrease of MAP, but aggravated the disturbances of microcirculation and shortened the survival time of animals, while L-Arg produced the contrary effects.

Conclusion: The results indicated that the large amount of NO in blood after burn may play an early protective role to injury.

本刊更多论文

[内源性一氧化氮对烧伤休克大鼠微循环的保护作用]。

目的:探讨一氧化氮(NO)在烧伤休克中的作用。方法:采用大鼠40% TBSA深ⅱ型烧伤模型。观察NO合成酶抑制剂L-NAME和NO合成前体L-Arg对动物平均动脉压(MAP)、肌肉微循环、血浆NO2(-)/NO3(-)浓度及存活时间的影响。结果:烧伤后一氧化氮的合成明显增加，同时伴有MAP的降低和肌肉微循环的紊乱。L-NAME抑制了MAP的下降，但加重了微循环的紊乱，缩短了动物的生存时间，而L-Arg则产生了相反的作用。结论:烧伤后血液中大量一氧化氮可能对损伤有早期保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns

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