[Influence of escharectomy during burn shock stage upon the changes in endothelin and NO].

Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns Pub Date : 1998-05-01

S Sun, L He, Z Guo

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Abstract

Objective: To observe influence of escharectomy during and after burn shock stage upon the changes in plasma ET and NO.

Methods: 35% TBSA full-thickness burn was produced in pigs, which were divided into two groups. Group S was a group undergoing escharectomy during burn shock stage at 24 h postburn. Group C was a group receiving escharectomy at 96 h after injury. ET and NO were determined and ET/NO was calculated.

Results: The levels of ET and NO were higher after injury than before injury in both groups. The level of ET was lower significantly in group S than in group C from 96 h postburn on. The level of NO was higher in group S than in group C. The ET/NO was lower in group S than in group C from PBH 24 on.

Conclusion: Escharectomy during burn shock stage was beneficial in reducing injury of endothelial cells, decreasing exudation and edema, decreasing tissue hypoxia and improving microcirculation.

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[烧伤休克期切痂对内皮素、NO变化的影响]。

目的:观察烧伤休克期及后切痂对血浆ET、NO变化的影响。方法:采用35% TBSA全层烧伤法，将猪分为两组。S组为烧伤休克后24 h行痂切除术组。C组为损伤后96 h行痂切除术组。测定ET和NO，计算ET/NO。结果:两组损伤后ET、NO水平均高于损伤前。燃烧后96 h, S组ET水平显著低于C组。从PBH 24开始，S组的NO水平高于C组，ET/NO低于C组。结论:烧伤休克期切痂有利于减轻内皮细胞损伤，减少渗出水肿，减少组织缺氧，改善微循环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns

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